HMGA1 protein is a positive regulator of the insulin-like growth factor-I receptor gene.

@article{Aiello2010HMGA1PI,
  title={HMGA1 protein is a positive regulator of the insulin-like growth factor-I receptor gene.},
  author={Aurora Aiello and G Pandini and Rive Sarfstein and Haim Werner and Guidalberto Manfioletti and Riccardo Vigneri and Antonino Belfiore},
  journal={European journal of cancer},
  year={2010},
  volume={46 10},
  pages={1919-26}
}
The IGF-I receptor (IGF-IR) is often overexpressed in cancer and is believed to play a crucial role in cancer progression. High Mobility Group A1 (HMGA1) is a non-histone chromatin protein that has the ability to regulate gene expression through DNA binding and involvement in enhanceosome complexes. HMGA1 is expressed at low level in adult differentiated cells, whereas it is expressed at high level in embryonic and malignant cells. We evaluated whether the HMGA1 aberrant expression has a role… CONTINUE READING

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