HMG chromosomal proteins in development and disease.

  title={HMG chromosomal proteins in development and disease.},
  author={Robert Hu Chang Hock and Takashi Furusawa and Tetsuya Ueda and Michael Bustin},
  journal={Trends in cell biology},
  volume={17 2},
The high mobility group (HMG) proteins are a superfamily of abundant and ubiquitous nuclear proteins that bind to DNA and nucleosomes and induce structural changes in the chromatin fiber. They are important in chromatin dynamics and influence DNA processing in the context of chromatin. Results emerging from studies of human disease, genetically modified mice and cells with altered HMG expression indicate that the expression of the HMG proteins is developmentally regulated and that changes in… CONTINUE READING

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