HMG I/Y regulates long-range enhancer-dependent transcription on DNA and chromatin by changes in DNA topology

@article{Bagga2000HMGIR,
  title={HMG I/Y regulates long-range enhancer-dependent transcription on DNA and chromatin by changes in DNA topology},
  author={Rajesh Bagga and Susan Michalowski and Rohit Sabnis and Jack D. Griffith and Beverly M. Emerson},
  journal={Nucleic acids research},
  year={2000},
  volume={28 13},
  pages={
          2541-50
        }
}
The nature of nuclear structures that are required to confer transcriptional regulation by distal enhancers is unknown. We show that long-range enhancer-dependent beta-globin transcription is achieved in vitro upon addition of the DNA architectural protein HMG I/Y to affinity-enriched holo RNA polymerase II complexes. In this system, HMG I/Y represses promoter activity in the absence of an associated enhancer and strongly activates transcription in the presence of a distal enhancer. Importantly… CONTINUE READING
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