HMG-CoA reductase inhibitors suppress macrophage growth induced by oxidized low density lipoprotein.

@article{Sakai1997HMGCoARI,
  title={HMG-CoA reductase inhibitors suppress macrophage growth induced by oxidized low density lipoprotein.},
  author={Masaharu Sakai and Shozo Kobori and Takeshi Matsumura and T Biwa and Yuichiro Sato and Tsukasa Takemura and Hideki Hakamata and Seikoh Horiuchi and Masayoshi Shichiri},
  journal={Atherosclerosis},
  year={1997},
  volume={133 1},
  pages={51-9}
}
3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors ameliorate atherosclerotic diseases in several models of vascular disease. This is largely due to their ability to reduce plasma cholesterol levels in vivo. Proliferation of cellular components is one of the major events in the development and progression of atherosclerotic lesions. We recently demonstrated that oxidized low density lipoprotein (Ox-LDL), a likely atherogenic lipoprotein present in vivo, is capable of inducing… CONTINUE READING

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