HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis.

@article{Merx2004HMGCoARI,
  title={HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis.},
  author={Marc W. Merx and Elisa A Liehn and Uwe Janssens and Rudolf L{\"u}tticken and Juergen Schrader and Peter Hanrath and Christian Weber},
  journal={Circulation},
  year={2004},
  volume={109 21},
  pages={2560-5}
}
BACKGROUND HMG-CoA reductase inhibitors, such as simvastatin, have been shown to exhibit pronounced immunomodulatory effects independent of lipid lowering but to date have not been used to treat severe inflammatory disease such as sepsis. We thus approached the question of whether treatment with simvastatin might improve cardiovascular function and survival in sepsis. METHODS AND RESULTS Mice treated with simvastatin and rendered septic by cecal ligation and perforation (CLP) show a mean… CONTINUE READING
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