HMG-CoA reductase inhibitor induces a transient activation of high affinity nerve growth factor receptor, trk, and morphological differentiation with fatal outcome in PC12 cells.

@article{Kumano2000HMGCoARI,
  title={HMG-CoA reductase inhibitor induces a transient activation of high affinity nerve growth factor receptor, trk, and morphological differentiation with fatal outcome in PC12 cells.},
  author={Takayuki Kumano and Tatsuro Mutoh and Hiroto Nakagawa and Masamitsu Kuriyama},
  journal={Brain research},
  year={2000},
  volume={859 1},
  pages={169-72}
}
The present study was aimed at investigating the possible toxicity of simvastatin on a neuronal cell line, PC12 cells. Simvastatin clearly induced a transient morphological differentiation as evidenced by the occurrence of neurite outgrowth with a transient activation of the high affinity nerve growth factor receptor, Trk, but died at 36 h after its… CONTINUE READING