HMG CoA reductase inhibition reduces sarcolemmal Na(+)-K(+) pump density.


OBJECTIVES HMG CoA reductase inhibitors reduce cellular availability of mevalonate, a precursor in cholesterol synthesis. Since the cholesterol content of cell membranes is an important determinant of Na(+)-K(+) pump function we speculated that treatment with HMG CoA reductase inhibitors affects Na(+)-K(+) pump activity. METHODS We treated rabbits and… (More)