HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis.

@article{Schulz2004HMGCoARI,
  title={HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis.},
  author={Joachim G Schulz and Julian B{\"o}sel and Magali Stoeckel and Dirk Megow and Ulrich Dirnagl and Matthias Endres},
  journal={Journal of neurochemistry},
  year={2004},
  volume={89 1},
  pages={
          24-32
        }
}
To determine whether neurite outgrowth depends upon the mevalonate pathway, we blocked mevalonate synthesis in nerve growth factor-treated PC12 cells or primary cortical neurones with atorvastatin, a 3-hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, and substituted different intermediates of the mevalonate pathway. We show that HMG-CoA reductase inhibition causes a profound reduction of neurite length, neurite loss and ultimatively cell death in undifferentiated and pre… CONTINUE READING
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