HMG-CoA Reductase Inhibitors Reduce Interleukin-6 Synthesis in Human Vascular Smooth Muscle Cells

@article{Ito2002HMGCoARI,
  title={HMG-CoA Reductase Inhibitors Reduce Interleukin-6 Synthesis in Human Vascular Smooth Muscle Cells},
  author={Takayuki Ito and Uichi Ikeda and Masahisa Shimpo and Ruri Ohki and Masafumi Takahashi and Keiji Yamamoto and Kazuyuki Shimada},
  journal={Cardiovascular Drugs and Therapy},
  year={2002},
  volume={16},
  pages={121-126}
}
Interleukin-6 (IL-6) is a key molecule in chronic inflammation and has been implicated in the progression of atherosclerosis. HMG-CoA reductase inhibitors (statins) may reduce the cardiovascular risk and vulnerability of atherosclerotic plaque through nonlipid as well as lipid-lowering mechanisms, but their anti-inflammatory effects on the vascular tissue have not been fully elucidated. We investigated the effects of fluvastatin on IL-6 synthesis in human vascular smooth muscle cells (VSMCs… CONTINUE READING
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