Corpus ID: 80706463

HMG-CoA Reductase Inhibitor Has Protective Effects Against Stroke Events in Stroke-Prone Spontaneously Hypertensive Rats

@inproceedings{SeinosukeKawashima2003HMGCoARI,
  title={HMG-CoA Reductase Inhibitor Has Protective Effects Against Stroke Events in Stroke-Prone Spontaneously Hypertensive Rats},
  author={SeinosukeKawashima and TomoyaYamashita and YoichiMiwa and Masanoriozaki and MasayukiNamiki and TetsuakiHirase and NobutakaInoue and Ken-ichiHirata and MitsuhiroYokoyama},
  year={2003}
}
Background and Purpose— Recent clinical studies suggest that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) exert protective effects against nonhemorrhagic stroke. In a murine cerebral ischemia model produced by occlusion of the middle cerebral artery, statins were shown to reduce infarct size. However, the effect of statins on hypertension-based stroke is unknown. The purpose of this study is to clarify the effect of a statin on stroke in stroke-prone… Expand
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