HMG-1 as a mediator of acute lung inflammation.

  title={HMG-1 as a mediator of acute lung inflammation.},
  author={Edward Abraham and John Arcaroli and Aaron B Carmody and Haichao Wang and Kevin J Tracey},
  journal={Journal of immunology},
  volume={165 6},
Acute inflammatory lung injury is often a delayed complication of critical illness and is associated with increased mortality. High mobility group-1 (HMG-1) protein, in addition to its role as a transcriptional regulatory factor, has recently been identified as a late mediator of endotoxin lethality. In the present studies, HMG-1 given intratracheally produced acute inflammatory injury to the lungs, with neutrophil accumulation, the development of lung edema, and increased pulmonary production… CONTINUE READING