HMB supplementation: clinical and athletic performance-related effects and mechanisms of action

@article{Zanchi2010HMBSC,
  title={HMB supplementation: clinical and athletic performance-related effects and mechanisms of action},
  author={Nelo E Zanchi and Frederico Gerlinger-Romero and Lucas Guimar{\~a}es‐Ferreira and M{\'a}rio Alves Siqueira Filho and Vitor Felitti and F{\'a}bio Santos Lira and Marilia Seelaender and Antonio Herbert Jr. Lancha},
  journal={Amino Acids},
  year={2010},
  volume={40},
  pages={1015-1025}
}
Amino acids such as leucine and its metabolite α-ketoisocaproate (KIC), are returning to be the focus of studies, mainly because of their anti-catabolic properties, through inhibition of muscle proteolysis and enhancement of protein synthesis. It is clear that these effects may counteract catabolic conditions, as well as enhance skeletal muscle mass and strength in athletes. Moreover, beta-hydroxy-beta-methylbutyrate (HMB) has been shown to produce an important effect in reducing muscle damage… Expand
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113 Citations
Highly Influential Citations
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Background Citations
37
Methods Citations
3
Results Citations
4

113 Citations

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23 – HMB Supplementation: Clinical and Performance-Related Effects and Mechanisms of Action
TLDR
This chapter aims to describe general scientific evidence on HMB supplementation with regard to clinical outcomes, as well as their effects associated with resistance training and other sports. Expand
Benefits of β-hydroxy-β-methylbutyrate supplementation in trained and untrained individuals
TLDR
Evidence regarding HMB’s role in limiting muscle degradation and increasing muscle protein synthesis has created an exciting interest in examining its efficacy among untrained individuals. Expand
Mechanism of Action and the Effect of Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation on Different Types of Physical Performance - A Systematic Review
Abstract Beta-hydroxy-beta-methylbutyrate (HMB) has been used extensively as a dietary supplement for athletes and physically active people. HMB is a leucine metabolite, which is one of three… Expand
Metabolic and functional effects of beta-hydroxy-beta-methylbutyrate (HMB) supplementation in skeletal muscle
TLDR
The proposition that HMB supplementation have marked change in oxidative metabolism improving muscle strength generation and performance during intense contractions is supported. Expand
Beta-hydroxy-beta-methylbutyrate supplementation in health and disease: a systematic review of randomized trials
TLDR
Most of the selected studies showed the effectiveness of HMB in preventing exercise-related muscle damage in healthy trained and untrained individuals as well as muscle loss during chronic diseases. Expand
USEFULNESS OF Β-HYDROXY-Β-METHYLBUTYRATE (HMB) SUPPLEMENTATION IN DIFFERENT SPORTS: AN UPDATE AND PRACTICAL IMPLICATIONS.
TLDR
The notion that HMB could help to attenuate tissue catabolism and initiate muscle anabolism particularly in untrained individuals exposed to strenuous exercise or when trained individual are exposed to periods of high physical stress is supported. Expand
β-Hydroxy-β-methylbutyrate (HMβ) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathway
TLDR
It is suggested that HMβ supplementation can be used to increase muscle mass without adverse health effects and expression of proteins involved in insulin signalling was increased only in liver. Expand
Supplementation with beta-hydroxy-beta-methylbutyrate impacts glucose homeostasis and increases liver size in trained mice.
  • I. Schadock, Barbara G Freitas, +10 authors C. Barros
  • Medicine, Chemistry
  • International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
  • 2018
TLDR
It is confirmed that HMB supplementation associated with intensive training protocol drives changes in glucose homeostasis and liver metabolism in mice. Expand
A Review of the Effects of Leucine Metabolite (β-Hydroxy-β-methylbutyrate) Supplementation and Resistance Training on Inflammatory Markers: A New Approach to Oxidative Stress and Cardiovascular Risk Factors
TLDR
The data presented here suggest that acute HMB supplementation may attenuate the pro-inflammatory response following an intense bout of resistance exercise in athletes and that chronic HMB consumption with resistance training does not improve cardiovascular risk factors and oxidative stress markers greater than resistance training alone. Expand
Effects of Leucine Metabolite (Β-Hydroxy-Β-Methylbutyrate) Supplementation and Resistance Training on Cardiovascular Risk Factors, Oxidative Stress, and Inflammatory Markers: a Review on Recent Literature
β-hydroxy β-methylbutyrate (HMB) is a bioactive metabolite formed from breakdown of the branched-chain amino acid leucine. Given the popularity of HMB supplements among different athletes,… Expand
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References

SHOWING 1-10 OF 101 REFERENCES
β-Hydroxy-β-Methylbutyrate (HMB) Supplementation and the Promotion of Muscle Growth and Strength
TLDR
There is clearly a need for more tightly controlled, longer duration studies to verify if HMB enhances strength and muscular hypertrophy development associated with resistance training across a range of groups, including resistance trained individuals. Expand
Beta-hydroxy-beta-methylbutyrate (HMB) supplementation and the promotion of muscle growth and strength.
TLDR
There is clearly a need for more tightly controlled, longer duration studies to verify if HMB enhances strength and muscular hypertrophy development associated with resistance training across a range of groups, including resistance trained individuals. Expand
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TLDR
Leucine has a potential role on attenuate skeletal muscle proteolysis and could help to sharpen the leucine efficacy on skeletal muscle protein degradation during several atrophic states. Expand
Effects of calcium beta-hydroxy-beta-methylbutyrate (HMB) supplementation during resistance-training on markers of catabolism, body composition and strength.
TLDR
Results indicate that 28 d of HMB supplementation during resistance-training does not reduce catabolism or affect training-induced changes in body composition and strength in experienced resistance-trained males. Expand
β-Hydroxy-β-methylbutyrate (HMβ) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathway
TLDR
It is suggested that HMβ supplementation can be used to increase muscle mass without adverse health effects and expression of proteins involved in insulin signalling was increased only in liver. Expand
Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review
TLDR
An in depth and objective analysis of HMB research is provided and a comprehensive discussion on possible mechanisms, which HMB may operate through is provided. Expand
Effect of β-hydroxy-β-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women
TLDR
It is indicated that daily supplementation of β-hydroxy-β-methylbutyrate, arginine, and lysine for 12 wk positively alters measurements of functionality, strength, fat-free mass, and protein synthesis, suggesting that the strategy of targeted nutrition has the ability to affect muscle health in elderly women. Expand
Nutritional role of the leucine metabolite β-hydroxy β-methylbutyrate (HMB)
TLDR
The results of both animal and human studies indicate that dietary supplementation of HMB is safe, as evidenced by lack of physical adverse effects and a lack of effect on blood hematology and chemistry. Expand
Supplementation with β-Hydroxy-β-Methylbutyrate ( HMB ) and α-Ketoisocaproic Acid ( KIC ) Reduces Signs and Symptoms of Exercise-Induced Muscle Damage in Man
This study examined the effects of β-hydroxyβ-methylbutyrate (HMB) and α-ketoisocaproic acid (KIC) supplementation on signs and symptoms of exercise-induced muscle damage following a single bout of… Expand
β-Hydroxy-β-Methylbutyrate (HMB) Supplementation in Humans Is Safe and May Decrease Cardiovascular Risk Factors
TLDR
Objective data collected across nine experiments indicate that HMB can be taken safely as an ergogenic aid for exercise and that objective measures of health and perception of well-being are generally enhanced. Expand
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