HMB supplementation: clinical and athletic performance-related effects and mechanisms of action

@article{Zanchi2010HMBSC,
  title={HMB supplementation: clinical and athletic performance-related effects and mechanisms of action},
  author={Nelo E Zanchi and Frederico Gerlinger-Romero and Lucas Guimar{\~a}es‐Ferreira and M{\'a}rio Alves Siqueira Filho and Vitor Felitti and F{\'a}bio Santos Lira and Marilia Seelaender and Antonio Herbert Jr. Lancha},
  journal={Amino Acids},
  year={2010},
  volume={40},
  pages={1015-1025}
}
Amino acids such as leucine and its metabolite α-ketoisocaproate (KIC), are returning to be the focus of studies, mainly because of their anti-catabolic properties, through inhibition of muscle proteolysis and enhancement of protein synthesis. It is clear that these effects may counteract catabolic conditions, as well as enhance skeletal muscle mass and strength in athletes. Moreover, beta-hydroxy-beta-methylbutyrate (HMB) has been shown to produce an important effect in reducing muscle damage… 
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Evidence regarding HMB’s role in limiting muscle degradation and increasing muscle protein synthesis has created an exciting interest in examining its efficacy among untrained individuals.
Mechanism of Action and the Effect of Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation on Different Types of Physical Performance - A Systematic Review
Abstract Beta-hydroxy-beta-methylbutyrate (HMB) has been used extensively as a dietary supplement for athletes and physically active people. HMB is a leucine metabolite, which is one of three
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TLDR
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EXERCISE-INDUCED HORMONAL RESPONSES TO HMB ADMINISTRATION: A SYSTEMATIC REVIEW AND META-ANALYSIS
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  • 2022
TLDR
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TLDR
The notion that HMB could help to attenuate tissue catabolism and initiate muscle anabolism particularly in untrained individuals exposed to strenuous exercise or when trained individual are exposed to periods of high physical stress is supported.
β-Hydroxy-β-methylbutyrate (HMβ) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathway
TLDR
It is suggested that HMβ supplementation can be used to increase muscle mass without adverse health effects and expression of proteins involved in insulin signalling was increased only in liver.
Supplementation with beta-hydroxy-beta-methylbutyrate impacts glucose homeostasis and increases liver size in trained mice.
  • I. SchadockBarbara G Freitas C. Barros
  • Medicine
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
  • 2018
TLDR
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A Review of the Effects of Leucine Metabolite (β-Hydroxy-β-methylbutyrate) Supplementation and Resistance Training on Inflammatory Markers: A New Approach to Oxidative Stress and Cardiovascular Risk Factors
TLDR
The data presented here suggest that acute HMB supplementation may attenuate the pro-inflammatory response following an intense bout of resistance exercise in athletes and that chronic HMB consumption with resistance training does not improve cardiovascular risk factors and oxidative stress markers greater than resistance training alone.
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TLDR
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There is clearly a need for more tightly controlled, longer duration studies to verify if HMB enhances strength and muscular hypertrophy development associated with resistance training across a range of groups, including resistance trained individuals.
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TLDR
It is suggested that HMβ supplementation can be used to increase muscle mass without adverse health effects and expression of proteins involved in insulin signalling was increased only in liver.
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TLDR
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