• DOI:10.1007/s00726-010-0678-0
• Corpus ID: 11120110

HMB supplementation: clinical and athletic performance-related effects and mechanisms of action

@article{Zanchi2010HMBSC,
  title={HMB supplementation: clinical and athletic performance-related effects and mechanisms of action},
  author={Nelo E Zanchi and Frederico Gerlinger-Romero and Lucas Guimar{\~a}es‐Ferreira and M{\'a}rio Alves Siqueira Filho and Vitor Felitti and F{\'a}bio Santos Lira and Marilia Seelaender and Antonio Herbert Jr. Lancha},
  journal={Amino Acids},
  year={2010},
  volume={40},
  pages={1015-1025}
}

• N. Zanchi, F. Gerlinger-Romero, +5 authors A. Lancha
• Published 1 April 2011
• Biology
• Amino Acids

Amino acids such as leucine and its metabolite α-ketoisocaproate (KIC), are returning to be the focus of studies, mainly because of their anti-catabolic properties, through inhibition of muscle proteolysis and enhancement of protein synthesis. It is clear that these effects may counteract catabolic conditions, as well as enhance skeletal muscle mass and strength in athletes. Moreover, beta-hydroxy-beta-methylbutyrate (HMB) has been shown to produce an important effect in reducing muscle damage induced by mechanical stimuli of skeletal muscle. This review aims to describe the general scientific evidence of KIC and HMB supplementation clinical relevance, as well as their effects (e.g., increases in skeletal muscle mass and/or strength), associated with resistance training or other sports. Moreover, the possible mechanisms of cell signaling regulation leading to increases and/or sparing (during catabolic conditions) of skeletal muscle mass are discussed in detail based on the recent literature.