HMB-45 and Melan-A are Useful in the Differential Diagnosis Between Granular Cell Tumor and Malignant Melanoma

@article{Gleason2007HMB45AM,
  title={HMB-45 and Melan-A are Useful in the Differential Diagnosis Between Granular Cell Tumor and Malignant Melanoma},
  author={Briana C. Gleason and Alessandra F. Nascimento},
  journal={The American Journal of Dermatopathology},
  year={2007},
  volume={29},
  pages={22-27}
}
Granular cell tumors (GCTs), especially if atypical or malignant, may share cytomorphologic and architectural features with malignant melanoma, when the latter shows granular cell change. In many cases, these neoplasms can be differentiated from each other on histologic grounds, but distinction may sometimes be challenging. By immunohistochemistry, both tumors are strongly positive for S-100 protein and frequently express other nonspecific markers such as CD68, NSE, and NKIC3. In the current… 
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Citation Type

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Primary malignant melanoma without melanosis of the colon
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References

SHOWING 1-10 OF 58 REFERENCES
Immunoprofile of MITF, Tyrosinase, Melan-A, and MAGE-1 in HMB45-Negative Melanomas
TLDR
MAGE-1, melanocyte-specific transcription factor, tyrosinase, and Melan-A are useful markers in the diagnosis of malignant melanocytic lesions when HMB45 is negative, andMelanocyte- specific transcription factor is not a useful marker for desmoplastic melanoma.
Expression of Melanocytic Differentiation Markers in Malignant Melanomas of the Oral and Sinonasal Mucosa
TLDR
Results reveal that T311 is the most sensitive marker for sinonasal melanomas and closely approaches the sensitivity of anti-S-100 protein for oral mucosal melanomas.
Granular cell tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation.
TLDR
The study expands the immunophenotype of GCT (S100, CD68, protein gene product 9.5, and inhibin-alpha) regardless of location and supports a neural origin.
An immunophenotypic survey of malignant melanomas
TLDR
An immunohistochemical study of 106 malignant melanoma specimens from 59 patients, using formalin‐fixed, paraffin‐embedded material, is reported, and one specimen showed α‐smooth muscle actin (αSMA) positivity.
Expression of melanocyte-associated markers gp-100 and Melan-A/MART-1 in angiomyolipomas
TLDR
It is shown that angiomyolipomas express the melanocyte-associated antigens Melan-A and gp-100 at the protein and at the mRNA level, suggesting a true expression of these antigen rather than cross-reacting epitopes.
CD99 immunoreactivity in atypical fibroxanthoma: a common feature of diagnostic value.
TLDR
It is believed that CD99 may be a helpful "positive" feature in the histopathologic diagnosis of AFX, and the first report of CD99 and PGP9.5 immunostaining in AFX is reported.
Microphthalmia Transcription Factor in the Immunohistochemical Diagnosis of Metastatic Melanoma: Comparison With Four Other Melanoma Markers
TLDR
Microphthalmia transcription factor may be a valuable addition to the marker panel used in diagnosing melanoma, in combination with S100, TYR, and the other markers, but it is not present in cases of desmoplastic melanomas.
Immunoreactivity of S100 protein, alpha-1-antitrypsin, and CD68 in adult and congenital granular cell tumors.
  • A. Filie, J. Lage, N. Azumi
  • Medicine, Biology
    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • 1996
TLDR
It is concluded that positive immunoreactivity for A1AT and CD68 in GCT may be a reflection of the intracytoplasmic accumulation of phagolysosomes and that it does not imply a histiocytic origin for this tumors.
KP1/CD68 expression in malignant neoplasms including lymphomas, sarcomas, and carcinomas.
TLDR
The results indicate that KP1 shows a relatively wide spectrum of immunoreactivity with malignant neoplasms of presumed non-histiocyte origin, thus arguing against its expected specificity and high value in diagnostic pathology.
Microphthalmia Transcription Factor Expression in Cutaneous Benign, Malignant Melanocytic, and Nonmelanocytic Tumors
TLDR
The results demonstrate that Mitf antibody expression is conserved in the majority of benign and malignant melanocytic lesions, and that it may be helpful in the diagnosis of primary melanocytical skin lesions.
...
1
2
3
4
5
...