HMB-45 and Melan-A are Useful in the Differential Diagnosis Between Granular Cell Tumor and Malignant Melanoma

@article{Gleason2007HMB45AM,
  title={HMB-45 and Melan-A are Useful in the Differential Diagnosis Between Granular Cell Tumor and Malignant Melanoma},
  author={Briana C. Gleason and Alessandra F. Nascimento},
  journal={The American Journal of Dermatopathology},
  year={2007},
  volume={29},
  pages={22-27}
}
Granular cell tumors (GCTs), especially if atypical or malignant, may share cytomorphologic and architectural features with malignant melanoma, when the latter shows granular cell change. In many cases, these neoplasms can be differentiated from each other on histologic grounds, but distinction may sometimes be challenging. By immunohistochemistry, both tumors are strongly positive for S-100 protein and frequently express other nonspecific markers such as CD68, NSE, and NKIC3. In the current… 
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