HLA-specific B cells: I. A method for their detection, quantification, and isolation using HLA tetramers.

@article{Zachary2007HLAspecificBC,
  title={HLA-specific B cells: I. A method for their detection, quantification, and isolation using HLA tetramers.},
  author={Andrea A. Zachary and Dessislava Kopchaliiska and Robert R. Montgomery and Mary S. Leffell},
  journal={Transplantation},
  year={2007},
  volume={83 7},
  pages={982-8}
}
BACKGROUND The development of highly sensitive and specific assays for detecting and characterizing HLA-specific antibodies has contributed to an appreciation of the extensive involvement of those antibodies in graft injury and dysfunction. However, understanding the regulatory processes of the humoral response to transplantation and the mechanisms underlying therapeutic agents and protocols for preventing and treating sensitization requires a way to study HLA-specific B cells. METHODS… CONTINUE READING