HLA-restricted epitope identification and detection of functional T cell responses by using MHC-peptide and costimulatory microarrays.

@article{Stone2005HLArestrictedEI,
  title={HLA-restricted epitope identification and detection of functional T cell responses by using MHC-peptide and costimulatory microarrays.},
  author={Jennifer D Stone and Walter E Demkowicz and Lawrence J Stern},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 10},
  pages={3744-9}
}
Identification of T cell epitopes is a vital but often slow and difficult step in studying the immune response to infectious agents and autoantigens. We report a spatially addressable technique for screening large numbers of T cell epitopes for both specific antigen recognition and functional activity induced. This system uses microarrays of immobilized, recombinant MHC-peptide complexes, costimulatory molecules, and cytokine-capture antibodies. The array elements act as synthetic antigen… CONTINUE READING

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