HLA-restricted epitope identification and detection of functional T cell responses by using MHC-peptide and costimulatory microarrays.


Identification of T cell epitopes is a vital but often slow and difficult step in studying the immune response to infectious agents and autoantigens. We report a spatially addressable technique for screening large numbers of T cell epitopes for both specific antigen recognition and functional activity induced. This system uses microarrays of immobilized… (More)


5 Figures and Tables