HLA-restricted T-cell recognition of Epstein–Barr virus-infected B cells

  title={HLA-restricted T-cell recognition of Epstein–Barr virus-infected B cells},
  author={Alan B. Rickinson and Lesley E. Wallace and M. Anthony Epstein},
In mice the cytotoxic T-cell response to several types of virus is influenced by genes within the major histocompatibility complex1–5; in particular, genetic control is exercised at the effector cell level through a requirement that virus-specific cytotoxic T cells recognise viral antigens in association with H–2K and H–2D region gene products on the surface of infected cells1,2. In man the restriction which the analogous HLA-A, -B and -C-region gene products might place on virus-specific T… CONTINUE READING


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