HLA mismatching within or outside of cross-reactive groups (CREGs) is associated with similar outcomes after unrelated hematopoietic stem cell transplantation.

@article{Wade2007HLAMW,
  title={HLA mismatching within or outside of cross-reactive groups (CREGs) is associated with similar outcomes after unrelated hematopoietic stem cell transplantation.},
  author={Judith A Wade and Carolyn K Hurley and Steven K. Takemoto and John A. Thompson and Stella M. Davies and Thomas C Fuller and Glenn Rodey and Dennis L. Confer and Harriet J. Noreen and Michael D. Haagenson and Fangyu Kan and John P. Klein and Mary Eapen and Stephen Spellman and Craig Kollman},
  journal={Blood},
  year={2007},
  volume={109 9},
  pages={4064-70}
}
The National Marrow Donor Program maintains a registry of volunteer donors for patients in need of a hematopoietic stem cell transplantation. Strategies for selecting a partially HLA-mismatched donor vary when a full match cannot be identified. Some transplantation centers limit the selection of mismatched donors to those sharing mismatched antigens within HLA-A and HLA-B cross-reactive groups (CREGs). To assess whether an HLA mismatch within a CREG group ("minor") may result in better outcome… CONTINUE READING
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