HLA-mismatched renal transplantation without maintenance immunosuppression.

@article{Kawai2008HLAmismatchedRT,
  title={HLA-mismatched renal transplantation without maintenance immunosuppression.},
  author={T. Kawai and A. Cosimi and T. Spitzer and N. Tolkoff-Rubin and M. Suthanthiran and S. Saidman and J. Shaffer and F. Preffer and R. Ding and V. Sharma and J. Fishman and B. Dey and D. Ko and M. Hertl and N. B. Goes and W. Wong and W. Williams and R. Colvin and M. Sykes and D. Sachs},
  journal={The New England journal of medicine},
  year={2008},
  volume={358 4},
  pages={
          353-61
        }
}
Five patients with end-stage renal disease received combined bone marrow and kidney transplants from HLA single-haplotype mismatched living related donors, with the use of a nonmyeloablative preparative regimen. Transient chimerism and reversible capillary leak syndrome developed in all recipients. Irreversible humoral rejection occurred in one patient. In the other four recipients, it was possible to discontinue all immunosuppressive therapy 9 to 14 months after the transplantation, and renal… Expand
805 Citations

Paper Mentions

Interventional Clinical Trial
This study will examine the safety and effectiveness of a combination kidney and bone marrow transplant from a haplo-identical related donor. An investigational medication and other… Expand
ConditionsEnd Stage Renal Disease
InterventionDrug, Radiation
Interventional Clinical Trial
In small initial studies, combined kidney and bone marrow transplants from the same donor have permitted some individuals to stop taking anti-rejection medicines without rejecting… Expand
ConditionsKidney Failure, Chronic, Kidney Transplantation
InterventionBiological, Drug, Procedure, (+1 more)
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Tolerance and Withdrawal of Immunosuppressive Drugs in Patients Given Kidney and Hematopoietic Cell Transplants
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