HLA-mismatched hematopoietic SCT without in vitro T-cell depletion for myelodysplastic syndrome

  title={HLA-mismatched hematopoietic SCT without in vitro T-cell depletion for myelodysplastic syndrome},
  author={Y H Chen and Kai Yan Liu and Lanping Xu and Huan Chen and Dai Hong Liu and Xiaohui Zhang and H Shi and Wei Han and Yu Wang and Ting Zhao and Jing-bo Wang and X-j Huang},
  journal={Bone Marrow Transplantation},
Allogeneic hematopoietic SCT (HSCT) is currently the only curative treatment for myelodysplastic syndrome (MDS). However, many patients cannot find an HLA-matched donor. We have developed a new protocol for HLA-mismatched (including haploidentical) HSCT using G-CSF-primed BM plus G-CSF-mobilized PBSCs without in vitro T-cell depletion. A total of 36 patients diagnosed with high-risk MDS (RAEB (refractory anemia with excess blasts) or RAEBt (RAEB in transformation)) underwent transplantation… CONTINUE READING
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siveness and polarization potential of T cells after in vitro mixture of G-CSF mobilized peripheral blood grafts and G-CSF primed bone marrow grafts in different proportions

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