HLA-linked genes and islet-cell antibodies in diabetes mellitus.

  title={HLA-linked genes and islet-cell antibodies in diabetes mellitus.},
  author={R. Lendrum and Glenda Walker and Andrew G. Cudworth and Jennifer Woodrow and D. R. Gamble},
  journal={British medical journal},
  volume={1 6025},
In a random series of 139 insulin-dependent diabetics aged 30 or under at the onset of disease islet-cell antibody (ICA) was detected in 33 cases (24%). In 27 patients who had had diabetes for less than one year 16 (59%) had ICA. Only one out of 51 patients with maturity onset diabetes who were not dependent on insulin were positive for ICA. Four out of 19 patients with late onset insulin-dependent diabetes had ICA. There was no association between the presence of ICA and any particular HLA… CONTINUE READING