HLA in transplantation

@article{Montgomery2018HLAIT,
  title={HLA in transplantation},
  author={Robert A. Montgomery and Vasishta S. Tatapudi and Mary S. Leffell and Andrea A. Zachary},
  journal={Nature Reviews Nephrology},
  year={2018},
  volume={14},
  pages={558-570}
}
The human major histocompatibility complex is a family of genes that encodes HLAs, which have a crucial role in defence against foreign pathogens and immune surveillance of tumours. In the context of transplantation, HLA molecules are polymorphic antigens that comprise an immunodominant alloreactive trigger for the immune response, resulting in rejection. Remarkable advances in knowledge and technology in the field of immunogenetics have considerably enhanced the safety of transplantation… CONTINUE READING
55
Twitter Mentions

Citations

Publications citing this paper.
SHOWING 1-7 OF 7 CITATIONS

Novel insights into non‐HLA alloimmunity in kidney transplantation

VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 146 REFERENCES

integrating paired donation into desensitization protocols

  • Montgomery, R. A. Renal transplantation across HLA, ABO antibody barriers
  • Am. J. Transplant. 10, 449–457
  • 2010
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

allograft gene expression profiling and response to treatment

  • Lefaucheur, C. et al. Complement activating anti HLA antibodies i transplantation
  • J. Am. Soc. Nephrol. 29, 620–635
  • 2018

evaluating DSA strength by titration

  • A. R. Tambur, Wiebe, C. HLA diagnostics
  • Transplantation 102, S23–S30
  • 2018

Assessment of Tocilizumab (Anti–Interleukin‐6 Receptor Monoclonal) as a Potential Treatment for Chronic Antibody‐Mediated Rejection and Transplant Glomerulopathy in HLA‐Sensitized Renal Allograft Recipients

  • Jua Choi, Olivier Aubert, +11 authors Stanley C. Jordan
  • Medicine
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2017