HLA has strongest association with IgA nephropathy in genome-wide analysis.

  title={HLA has strongest association with IgA nephropathy in genome-wide analysis.},
  author={John Feehally and Martin Farrall and Anne Boland and Daniel P Gale and Ivo G Gut and Simon Heath and Ashish Kumar and John F. Peden and Patrick Henry Maxwell and David Lester Morris and Sandosh Padmanabhan and Timothy J Vyse and Anna Zawadzka and Andrew J Rees and Mark Lathrop and Peter J Ratcliffe},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={21 10},
Demographic and family studies support the existence of a genetic contribution to the pathogenesis of IgA nephropathy, but results from genetic association studies of candidate genes are inconsistent. To systematically survey common genetic variation in this disease, we performed a genome-wide analysis in a cohort of patients with IgA nephropathy selected from the UK Glomerulonephritis DNA Bank. We used two groups of controls: parents of affected individuals and previously genotyped, unaffected… CONTINUE READING


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