HLA-haploidentical bone marrow transplantation in three infants with adenosine deaminase deficiency: Stable immunological reconstitution and reversal of skeletal abnormalities

@article{BluettersSawatzki1989HLAhaploidenticalBM,
  title={HLA-haploidentical bone marrow transplantation in three infants with adenosine deaminase deficiency: Stable immunological reconstitution and reversal of skeletal abnormalities},
  author={Renate Bluetters-Sawatzki and W. Friedrich and Wolfram Ebell and U A Vetter and Helmut St{\"o}ss and Shraga Felix Goldmann and Enno Kleihauer},
  journal={European Journal of Pediatrics},
  year={1989},
  volume={149},
  pages={104-109}
}
Three infants with severe combined immunodeficiency and adenosine deaminase (ADA) deficiency were treated by T-cell depleted bone marrow transplantation (BMT), using human leukocyte antigen (HLA)-haploidentical parents as donors. In the first patient, two initial transplants failed to engraft and no change of the immunodeficiency was observed. In order to overcome this graft resistance, cytoreductive conditioning was used prior to a third transplant. In the other two patients, similar… CONTINUE READING
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