HLA gene and haplotype frequencies in Russians, Bashkirs and Tatars, living in the Chelyabinsk Region (Russian South Urals)

@article{Suslova2012HLAGA,
  title={HLA gene and haplotype frequencies in Russians, Bashkirs and Tatars, living in the Chelyabinsk Region (Russian South Urals)},
  author={Tatiana A Suslova and A. L. Burmistrova and M S Chernova and E. B. Khromova and Ekaterina Lupar and S. V. Timofeeva and I. V. Devald and Mikhail N. Vavilov and C. Darke},
  journal={International Journal of Immunogenetics},
  year={2012},
  volume={39}
}
We have characterized the HLA‐A, ‐B, ‐DRB1, ‐DQA1 and ‐DQB1 profiles of three major ethnic groups living in Chelyabinsk Region of Russian South Urals, viz., Russians (n = 207), Bashkirs (n = 146) and Tatars (n = 135). First field level typing was performed by PCR using sequence‐specific primers. Estimates included carriage and gene frequencies, linkage disequilibrium and its significance and related values. Population comparisons were made between the allele family frequencies of the three… 
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References

SHOWING 1-10 OF 63 REFERENCES
HLA Genes in the Chuvashian Population from European Russia: Admixture of Central European and Mediterranean Populations
TLDR
Present-day Chuvash who speak an Altaic-Turkic language are probably more closely related to ancient Mesopotamian-Hittites and northern European populations than to central Asia-Altaic people.
HLA molecular markers in Tuvinians: a population with both Oriental and Caucasoid characteristics
TLDR
HLA class I and class II alleles have been studied for the first time in the Turkish‐speaking Tuvinian population, which lives in Russia, North of Mongolia and close to the Altai mountains and the ‘more than one wave’ model for the peopling of the Americas is supported.
HLA genes in Macedonians and the sub-Saharan origin of the Greeks.
TLDR
Genetic distances are closer between Greeks and Ethiopian/ sub-Saharan groups than to any other Mediterranean group and Greeks cluster with Ethiopians/sub-Saharans in both neighbour joining dendrograms and correspondence analyses.
Origin and affinities of indigenous Siberian populations as revealed by HLA class II gene frequencies
TLDR
Phylogenetic analysis of the frequency data suggests that the HLA genes of Asian and indigenous American populations stem from a single pool distinct from the gene pools of European and African populations.
Distributions of HLA class I alleles and haplotypes in Bulgarians--contribution to understanding the origin of the population.
TLDR
It is suggested that the Bulgarian population is characterized by the features of the Southern European anthropological type with some influence of other groups such as Asians, Turks, Armenians.
HLA polymorphism in Bulgarians defined by high-resolution typing methods in comparison with other populations.
TLDR
The HLA-A,B, -DRB1 allele and haplotype diversity defined by high-resolution DNA methods confirm that the Bulgarian population is characterized by features of southern European anthropological type with some influence of additional ethnic groups.
HLA alleles and haplotypes in the Turkish population: relatedness to Kurds, Armenians and other Mediterraneans.
TLDR
It is concluded that this invasion had a relatively few invaders in comparison to the already settled populations, i.e. Anatolian Hittite and Hurrian groups (older than 2000 B.C.), which may have given rise to present-day Kurdish, Armenian and Turkish populations.
HLA class II molecular polymorphisms in healthy Slavic individuals from North-Western Russia.
TLDR
Allele and haplotype frequencies were found to be similar to those observed in other Caucasian populations, with the exception of considerably high prevalence of the DPB1*0301 allele in the group studied.
Genetic origin of the Swedish Sami inferred from HLA class I and class II allele frequencies
TLDR
High-resolution typing of the class I HLA-A and -B loci and the class II DRB1, DQB1 and DQA1 loci in the northern and southern Swedish Sami indicates a higher proportion of Asian ancestry in the Sami than shown by previous genetic studies.
HLA class II gene polymorphism in Parsees and Zoroastrians of Iran
TLDR
This study will serve as a reference for further anthropological studies when the HLA profile of all ethnic groups of Iran is investigated, and Neighbour‐joining tree based on Nei's genetic distances according to DRB1 and DQB1 allele frequencies showed that Parsees and Zoroastrians of Iran were located in the same cluster of the phylogenetic tree.
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