HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells.

@article{Blanc2003HLAEA,
  title={HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells.},
  author={Katarina le Blanc and Charlotte Tammik and Kerstin Rosendahl and Eva Zetterberg and Olle Ringd{\'e}n},
  journal={Experimental hematology},
  year={2003},
  volume={31 10},
  pages={890-6}
}
OBJECTIVE Mesenchymal stem cells (MSC) do not elicit alloreactive lymphocyte responses due to immune modulations. We investigated the immunologic properties of MSC after differentiation along three lineages: bone, cartilage, and adipose. METHODS AND RESULTS Flow cytometry showed that undifferentiated MSC express HLA class I but not class II, although HLA class II was present intracellularly as detected by Western blot. Addition of interferon gamma (IFN-gamma) for 48 hours induced greater than… CONTINUE READING
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