HLA-dependent hypersensitivity to nevirapine in Sardinian HIV patients.

  title={HLA-dependent hypersensitivity to nevirapine in Sardinian HIV patients.},
  author={Roberto Littera and Carlo Carcassi and Alessandro Masala and Paola Piano and Paolo Serra and Francesco Ortu and Nicoletta Corso and Basilia Casula and Giorgio La Nasa and Licinio Contu and Paolo Emilio Manconi},
  volume={20 12},
BACKGROUND Hypersensitivity reaction to nevirapine, which in some cases can be fatal, shows a higher prevalence in Sardinia in comparison with other Italian regions. OBJECTIVE This study demonstrates that hypersensitive reaction to nevirapine in Sardinian HIV-infected patients is associated with the HLA Cw8-B14 haplotype. These two HLA class I antigens are in strong linkage disequilibrium in the Sardinian population. METHODS Forty-nine Sardinian HIV-positive patients treated with nevirapine… CONTINUE READING
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