HLA class II sequence variants influence tuberculosis risk in populations of European ancestry

  title={HLA class II sequence variants influence tuberculosis risk in populations of European ancestry},
  author={Gardar Sveinbjornsson and Daniel Fannar Gudbjartsson and Bjarni V Halldorsson and Karl G. Kristinsson and M Gottfredsson and Jeffrey C. Barrett and L{\'a}rus J. Gudmundsson and Kai Blondal and Arnaldur Gylfason and Sigurjon Axel Gudjonsson and Hafdis Th Helgadottir and Adalbjorg Jonasdottir and Aslaug Jonasdottir and Ari K{\'a}rason and Ljiljana Bulat Kardum and Jelena Kne{\vz}evi{\'c} and Helgi Kristjansson and M{\'a}r Kristj{\'a}nsson and Arthur Love and Yang C. Luo and Olafur Th. Magnusson and Patrick Sulem and Augustine Kong and G{\'i}sli M{\'a}sson and Unnur Thorsteinsdottir and Zlatko Dembic and Sergey Nejentsev and Thorsteinn Blondal and Ingileif J{\'o}nsd{\'o}ttir and K{\'a}ri Stef{\'a}nsson},
  booktitle={Nature Genetics},
Mycobacterium tuberculosis infections cause 9 million new tuberculosis cases and 1.5 million deaths annually. To identify variants conferring risk of tuberculosis, we tested 28.3 million variants identified through whole-genome sequencing of 2,636 Icelanders for association with tuberculosis (8,162 cases and 277,643 controls), pulmonary tuberculosis (PTB) and M. tuberculosis infection. We found association of three variants in the region harboring genes encoding the class II human leukocyte… CONTINUE READING
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