HLA class II linkage disequilibrium and haplotype evolution in the Cayapa Indians of Ecuador.

@article{Trachtenberg1995HLACI,
  title={HLA class II linkage disequilibrium and haplotype evolution in the Cayapa Indians of Ecuador.},
  author={Elizabeth A. Trachtenberg and Henry A. Erlich and Olga Rickards and G F DeStefano and William J. Klitz},
  journal={American journal of human genetics},
  year={1995},
  volume={57 2},
  pages={415-24}
}
DNA-based typing of the HLA class II loci in a sample of the Cayapa Indians of Ecuador reveals several lines of evidence that selection has operated to maintain and to diversify the existing level of polymorphism in the class II region. As has been noticed for other Native American groups, the overall level of polymorphism at the DRB1, DQA1, DQB1, and DPB1 loci is reduced relative to that found in other human populations. Nonetheless, the relative evenness in the distribution of allele… CONTINUE READING