HLA class II influences the immune response and antibody diversification to Ro60/Sjögren's syndrome-A: heightened antibody responses and epitope spreading in mice expressing HLA-DR molecules.

@article{Paisansinsup2002HLACI,
  title={HLA class II influences the immune response and antibody diversification to Ro60/Sj{\"o}gren's syndrome-A: heightened antibody responses and epitope spreading in mice expressing HLA-DR molecules.},
  author={Tawatchai Paisansinsup and Umesh S. Deshmukh and Vaidehi R. Chowdhary and Harvinder S. Luthra and Shu Man Fu and Chella S. David},
  journal={Journal of immunology},
  year={2002},
  volume={168 11},
  pages={5876-84}
}
Abs to Ro/SSA Ags in the sera of patients with systemic lupus erythematosus and Sjögren's syndrome are influenced by the HLA class II genes. To investigate the role of individual HLA class II genes in immune responses to human Ro60 (hRo60), mice lacking murine class II molecules and carrying either HLA genes DR2(DRB1*1502), DR3(DRB1*0301), DQ6(DQA1*0103/DQB1*0601), or DQ8(DQA1*0301/DQB1*0302), were immunized with rhRo60. The results show that hRo60 induces strong T and B cell responses in DR2… CONTINUE READING

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