HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin

@article{PujolBorrell1987HLACI,
  title={HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin},
  author={Ricardo Pujol–Borrell and I. A. D. Todd and Mala Doshi and Gian Franco Bottazzo and Robert Sutton and Derek Gary and Gunther R. Adolf and Marc Feldmann},
  journal={Nature},
  year={1987},
  volume={326},
  pages={304-306}
}
HLA class II molecules are surface glycoproteins which are essential in the initiation of immune responses. It has been postulated that induction of class II in epithelial cells such as endocrine cells, which are normally class II negative1, may result in autoimmunity2. In type I diabetes, islet beta cells, the target of the autoimmune process, selectively express class II antigens3,4. But in contrast to most other cell types5, islet beta cells are not stimulated to express class II by… CONTINUE READING