HLA class II-associated polymorphism of interferon-gamma production. Implications for HLA-disease association.

@article{Petrovsky1997HLACI,
  title={HLA class II-associated polymorphism of interferon-gamma production. Implications for HLA-disease association.},
  author={Nikolai Petrovsky and Leonard C. Harrison},
  journal={Human immunology},
  year={1997},
  volume={53 1},
  pages={12-6}
}
One of several possible mechanisms for the HLA-disease association is HLA-related polymorphism of cytokine expression. However, with the exception of the tumor necrosis factors, no evidence has been found for a relationship between HLA alleles and cytokine expression. This may be because cytokine responses to commonly employed mitogens are neither antigen nor HLA dependent, and responses to recall antigens are dominated by the effect of prior antigen exposure. We reasoned that responses to… CONTINUE READING

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