HLA class II and response to interferon-beta in multiple sclerosis.

@article{Fernndez2005HLACI,
  title={HLA class II and response to interferon-beta in multiple sclerosis.},
  author={Oscar Fern{\'a}ndez and Val Fern{\'a}ndez and Cristobalina Mayorga and Miguel {\'A}ngel V{\'a}zquez Guerrero and Antonio Ruiz de Le{\'o}n and Jose Antonio Tamayo and Fabiola Romero and Laura Alvarado Leyva and Antonio Alonso and Gloria Luque and Edificio Ram{\'o}n},
  journal={Acta neurologica Scandinavica},
  year={2005},
  volume={112 6},
  pages={
          391-4
        }
}
OBJECTIVE To study the relationship between human leucocyte antigen (HLA) genotype and clinical response to interferon-beta (IFN-beta). METHODS We analysed the HLA class II genotypes of 96 multiple sclerosis (MS) patients treated with IFN-beta. The patients were classified as responders or non-responders according to clinical criteria: one or more relapses or a sustained increase after 1 year treatment compared with the year prior to IFN-beta therapy of > or = 0.5 points on the Expanded… CONTINUE READING
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