HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families

@article{Erlich1993HLACI,
  title={HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families},
  author={Henry A. Erlich and Adina Zeidler and Julie Elizabeth Chang and Sylvia Shaw and Leslie J. Raffel and William J. Klitz and Yolanda Beshkov and Gertrude E Costin and Sheila Pressman and Teodorica L. Bugawan and Jerome I. Rotter},
  journal={Nature Genetics},
  year={1993},
  volume={3},
  pages={358-364}
}
The role of HLA class II alleles in genetic predisposition to insulin dependent diabetes mellitus (IDDM) was examined by PCR/oligonucleotide probe typing of 42 Mexican-American IDDM families derived from Hispanic Caucasians and Native Americans. All high risk haplotypes (HLA-DR3 and DR4) were of European origin while the most strongly protective haplotype (DRB1*1402) was Native American. Of the 16 DR-DQ DR4 haplotypes identified, only those bearing DQB1*0302 conferred risk; the DRB1 allele… CONTINUE READING