HLA class II alleles and chronic hepatitis C virus infection.

  title={HLA class II alleles and chronic hepatitis C virus infection.},
  author={L O F Cangussu and Ros{\^a}ngela Teixeira and {\'E}rika Fernandes Campos and Gisele Fabianne Rampim and Sueli A. Mingoti and O. A. Martins-Filho and Maria Gerbase-Delima},
  journal={Scandinavian journal of immunology},
  volume={74 3},
The aim of this study was to investigate association of human leucocyte antigens (HLA)-DRB1 and DQB1 polymorphisms with hepatitis C virus (HCV) infection and with the occurrence of severe liver fibrosis/cirrhosis in chronically infected patients. Ninety-nine white patients, from southeast Brazil, with confirmed HCV chronic infection were included in the study. Severe fibrosis/cirrhosis (METAVIR scores F3-F4) was present in 49 patients. HLA-DRB1 specificities and DRB1*11 and DQB1* alleles were… CONTINUE READING
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