HLA class I expression in metastatic melanoma correlates with tumor development during autologous vaccination

@article{Cabrera2006HLACI,
  title={HLA class I expression in metastatic melanoma correlates with tumor development during autologous vaccination},
  author={Teresa Cabrera and Ester Lara and Jos{\'e} Mar{\'i}a Romero and Isabel Maleno and Luis M. Real and Francisco Javier S{\'a}nchez Ruiz-Cabello and Pedro Valero and Francisco M. Camacho and Federico Garrido},
  journal={Cancer Immunology, Immunotherapy},
  year={2006},
  volume={56},
  pages={709-717}
}
Our knowledge of the mechanisms underlying tumor-specific immune response and tumor escape has considerably increased. HLA class I antigen defects remain an important tumor escape mechanism since they influence the interactions between tumor cells and specific T and NK cells in the course of malignant disease. We have studied here HLA class I expression in six subcutaneous metastases obtained from a melanoma patient immunized with an autologous melanoma cell vaccine (M-VAX). We report in this… CONTINUE READING

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