HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load.

@article{Rousseau2008HLACI,
  title={HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load.},
  author={Christine M. Rousseau and Marcus G. Daniels and Jonathan M. Carlson and Carl M. Kadie and Hayley Crawford and Andrew E Prendergast and Philippa Matthews and Rebecca Payne and Morgane Rolland and Dana N. Raugi and Brandon Maust and Gerald H. Learn and David C. Nickle and Hoosen Mahomed Coovadia and Thumbi Ndung'u and Nicole Frahm and Christian Brander and Bruce D. Walker and Philip J. R. Goulder and Tanmoy Bhattacharya and David E. Heckerman and Bette T Korber and James I. Mullins},
  journal={Journal of virology},
  year={2008},
  volume={82 13},
  pages={6434-46}
}
Human immunodeficiency virus type 1 (HIV-1) mutations that confer escape from cytotoxic T-lymphocyte (CTL) recognition can sometimes result in lower viral fitness. These mutations can then revert upon transmission to a new host in the absence of CTL-mediated immune selection pressure restricted by the HLA alleles of the prior host. To identify these potentially critical recognition points on the virus, we assessed HLA-driven viral evolution using three phylogenetic correction methods across… CONTINUE READING

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A new, core elements approach to vaccine immunogen design

  • M. Rolland, D. C. Nickle, J. I. Mullins
  • PLoS Pathog. 3:e157
  • 2007
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