HLA associations with Hashimoto's thyroiditis.

@article{Tandon1991HLAAW,
  title={HLA associations with Hashimoto's thyroiditis.},
  author={Nikhil Tandon and L Zhang and Anthony P. Weetman},
  journal={Clinical endocrinology},
  year={1991},
  volume={34 5},
  pages={383-6}
}
There is disagreement over the HLA-DR associations of Hashimoto's (goitrous) thyroiditis. We have studied 86 English Caucasian patients with this condition whose DR types were determined by restriction fragment polymorphism analysis. HLA-DR3 was significantly more frequent in these patients than in 100 controls (chi 2 = 7.09; P less than 0.01). The relative risk was 2.23 and aetiological fraction 0.29. HLA-DPB and DQB alleles were analysed in a proportion of these subjects by enzymatic DNA… CONTINUE READING

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