HLA-associated insulin autoantibody formation in newly diagnosed type I diabetic patients.

@article{Ziegler1991HLAassociatedIA,
  title={HLA-associated insulin autoantibody formation in newly diagnosed type I diabetic patients.},
  author={Anette-Gabriele Ziegler and Eberhard Standl and Ekkehard Albert and Hellmut Mehnert},
  journal={Diabetes},
  year={1991},
  volume={40 9},
  pages={1146-9}
}
To assess a possible HLA association with anti-insulin autoantibodies (IAAs) in human insulin-dependent (type I) diabetes, 51 newly diagnosed type I diabetic patients (mean age 22 +/- 8 yr) were typed for HLA-DR and HLA-DQ and studied for IAAs before exogenous insulin therapy with a competitive radioimmunoassay (normal range less than or equal to 49 nU/ml). The level of IAAs in 16 patients exceeded our upper limit of normal, and 18 had high-titer islet cell antibodies (ICAs; greater than or… CONTINUE READING

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