• Corpus ID: 43372952

HLA antigens in juvenile dermatitis herpetiformis.

@article{Richiardi1981HLAAI,
  title={HLA antigens in juvenile dermatitis herpetiformis.},
  author={Patricia Momigliano Richiardi and Iolanda Borelli and Fabio Malavasi and Emilio Sergio Curtoni and Emilio Berti and F Gianotti and Alberto Giannetti},
  journal={Acta dermato-venereologica},
  year={1981},
  volume={61 3},
  pages={
          241-4
        }
}
The incidence of histocompatibility antigens HLA-A, B, C, DR was studied in 32 Italian children with dermatitis herpetiformis. A significantly increased relative risk was found for B8 (R.R.=6.2), which was present in 50% of the patients as against 14% of the controls and for DR3 (R.R.=11.7), present in 69% of the patients as against 16%. DR7 also appeared to be increased, but only among DR3-negative patients. There was no significant difference in the incidence of DR3 between children with… 
10 Citations
HLA Antigens, Jejunal Morphology and Associated Diseases in Children with Dermatitis Herpetiformis
TLDR
A strong association with HLA‐B8 was found in patients of both nationalities, and atopic eczema occurred in 20 % of the patients and family history of atopy seemed to have an inverse correlation with HBA8 and DR3.
HLA IN JUVENILE DERMATITIS HERPETIFORMIS: CLINICAL HETEROGENEITY CORRELATED WITH DNA AND SEROLOGICAL POLYMORPHISM
TLDR
It is suggested that the susceptibility to Juvenile DH is determined by the same genes, within the HLA region, that are associated with Coeliac Disease.
Childhood dermatitis herpetiformis.
Immunogenetics of dermatitis herpetiformis.
IMMUNOGLOBULIN AND HLA‐DP GENES CONTRIBUTE TO THE SUSCEPTIBILITY TO JUVENILE DERMATITIS HERPETIFORMIS
  • G. Mazzola, M. Berrino, A. Amoroso
  • Biology, Medicine
    European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics
  • 1992
TLDR
The hypothesis of a multifactorial inheritance of DH, the HLA and Ig constant heavy chain genes being some of the loci contributing to the susceptibility is supported and data confirm that DP subregion is probably involved in the pathogenesis of DH.
Long-term follow-up of dermatitis herpetiformis in children.
Dermatitis herpetiformis: jejunal findings and skin response to gluten free diet.
TLDR
It is confirmed that most children with dermatitis herpetiformis have jejunal villous atrophy, though they rarely have gastrointestinal symptoms, and that a gluten free diet helps the damagedJejunal mucosa to recover and controls the rash even in those children who do not have an abnormal jeJunal biopsy.
Dermatitis herpetiformis: jejunal findings and skin
TLDR
Fifty seven children with dermatitis herpetiformis, 18 from Finland and 39 from Hungary, were studied and symptoms suggesting small intestinal disease were rare but in 35 (61%) of the children subtotal villous atrophy and in 16 (28%) partial villousatrophy were found.
gluten free diet . findings and skin response to Dermatitis herpetiformis : jejunal and
TLDR
Fifty seven children with dermatitis herpetiformis, 18 from Finland and 39 from Hungary, were studied and symptoms suggesting small intestinal disease were rare but in 35 (61%) of the children subtotal villous atrophy and in 16 (28%) partial villousatrophy were found.
The HLA‐dermatosis connection
TLDR
The pathogenic role of HLA in susceptibility to specific dermatological diseases often remains unclear and can be related to different disease courses, various anatomical predilection sites and used as a diagnostic tool.