HLA and smoking in prediction and prognosis of small cell lung cancer in autoimmune Lambert-Eaton myasthenic syndrome.

@article{Wirtz2005HLAAS,
  title={HLA and smoking in prediction and prognosis of small cell lung cancer in autoimmune Lambert-Eaton myasthenic syndrome.},
  author={Paul Willem Wirtz and Nick Willcox and Arno R. van der Slik and Bethan Lang and Paul Maddison and Bobby P. C. Koeleman and Marius J. Giphart and Axel R. Wintzen and Bart O Roep and Jan J G M Verschuuren},
  journal={Journal of neuroimmunology},
  year={2005},
  volume={159 1-2},
  pages={230-7}
}
Patients with small cell lung cancer (SCLC) survive longer if they have the antibody-mediated Lambert-Eaton myasthenic syndrome (LEMS), making this autoimmune disorder a prototype disease for studying cancer immunosurveillance. Patients with nontumor LEMS (NT-LEMS) never develop SCLC but are otherwise indistinguishable clinically. Therefore, we have compared immunogenetic factors in SCLC-LEMS and NT-LEMS and studied their role in the pathogenesis of LEMS and survival from SCLC. In 48 British… CONTINUE READING