HLA and other gene associations with dengue disease severity.

@article{Stephens2010HLAAO,
  title={HLA and other gene associations with dengue disease severity.},
  author={Henry A. F. Stephens},
  journal={Current topics in microbiology and immunology},
  year={2010},
  volume={338},
  pages={99-114}
}
Large case control gene association studies have been performed on cohorts of dengue virus (DENV) infected patients identified in mainland Southeast Asia, South Asia and the Caribbean. Candidate genes that have shown statistically significant associations with DENV disease severity encode HLA molecules, cell receptors for IgG (FcGII), vitamin D and ICAM3 (DCSIGN or CD209), pathogen recognition molecules such as mannose binding lectin (MBL), blood related antigens including ABO and human… CONTINUE READING
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