HLA and mate selection

  title={HLA and mate selection},
  author={Leon T. Rosenberg and Debra Cooperman and Rose Payn},
HLA types of the partners in 1017 couples were determined. It appeared that there was statistically significant occurrence of like types more frequently than predicted by chance. The existence of ethnic or racial groups with characteristically different frequencies of the HLA types might explain the result. 
Genetic Considerations in Human Sex‐Mate Selection: Partners Share Human Leukocyte Antigen but not Short‐Tandem‐Repeat Identity Markers
Investigating sex‐mate preferences in the contemporary Israeli population is of further curiosity being a population with distinct genetic characteristics, where multifaceted cultural considerations influence mate selection. Expand
Balancing selection and MHC
Although there is much yet to be understood about the mechanism and extent of balancing selection at MHC, new advances in molecular genetic technology and increasing interest in MHC from many types of biologists promise answers in the near future. Expand
Marriage does not relate to major histocompatibility complex: a genetic analysis based on 3691 couples
There is no pattern of MHC dis-assortative mating in a genetically diverse Western society, and the question of olfactory mate preference, in-group mating bias and the high polymorphism are discussed as potential explanations. Expand
MHC-Dependent Mate Selection within 872 Spousal Pairs of European Ancestry from the Health and Retirement Study
The analyses did not support a significant role of MHC dissimilarity in human mate choice and investigated fine scale mating patterns by testing for deviations from random mating at individual SNPs, HLA genes, and amino acids in HLA molecules. Expand
Influence of HLA on human partnership and sexual satisfaction
It is shown on a large sample (N = 508), with high-resolution typing of HLA class I/II, that HLA dissimilarity correlates with partnership, sexuality and enhances the desire to procreate, and concludes that Hla mediates mate behaviour in humans. Expand
MHC-based patterns of social and extra-pair mate choice in the Seychelles warbler
MHC-dependent EPP may provide indirect benefits in the Seychelles warbler if survival is positively linked to MHC diversity, as female choice will result in offspring of higher MHC Diversity, rather than the 'genetic compatibility' hypothesis. Expand
Examining the evidence for major histocompatibility complex-dependent mate selection in humans and nonhuman primates
Compounds of the major histocompatibility complex (MHC) are integral for effec- tive vertebrate adaptive immune response, and are also implicated as cues for sexual selection. The evidence for thisExpand
Does inbreeding lead to decreased human fertility?
Fertility in first cousin unions was positively influenced by a number of variables, including illiteracy, earlier age at marriage and lower contraceptive uptake, but the most important of these parameters were duration of marriage and reproductive compensation. Expand
Patterns of MHC‐dependent mate selection in humans and nonhuman primates: a meta‐analysis
The results indicate that preference for more MHC‐diverse mates is significant for humans and likely conserved across primates, and suggests that human assortative mating biases may be responsible for some patterns of MHC-based mate choice. Expand
Common HLA Alleles Associated with Health, but Not with Facial Attractiveness
Findings that support a new hypothesis relating HLA to health and a new method to quantify the level of heterozygosity are reported, which proposes that certain common HLA alleles confer resistance to prevalent pathogens. Expand


Common HLA antigens in couples with repeated abortions.
A significantly higher frequency of common HLA antigens was shared by both members of the couples with repeated abortions as compared to controls, suggesting the possibility of a higher incidence of homozygotic fetuses for certain HLAAntigens which may lead to abortions. Expand
Mapping of anH-2-linked gene that influences mating preference in mice
Results conform to a hypothesis that in the Qa-T1a region there is anRi (recognition of identity) gene which is expressed in females and influences mating preference; and that anotherRi gene, expressed in males and also influencing mating preference, is situated elsewhere in the MHC region. Expand
Absence of HLA association or linkage for variations in sensitivity to the odor of androstenone
Analysis of HLA antigens among 61 human mating pairs provided no evidence that HLA phenotypes play a role in human mating preference, and data fail to support a role for the human HLA system in the recognition of an odorant of potential biological significance. Expand
Mating preferences of F2 segregants of crosses between MHC-congenic mouse strains
It appears that the familial MHC genotypes of mice and the environment in which the colonies are maintained influence their MHC-related mating preference, but it has yet to be decided whether these factors operate by determining exposure to particular MHC haplotypes. Expand
Control of mating preferences in mice by genes in the major histocompatibility complex
These findings conform to a provisional model in which olfactory mating preference is governed by two linked genes in the region of H-2, one for the female signal andOne for the male receptor, and this suggests memory, but fortuitous bias is not excluded. Expand
The challenge of the early days of human histocompatibility
It was with great pleasure that the editors of Immunogenetics asked me to record some of my personal memories of the early some might call them h e r o i c years of histocompatibility, and in doing so, I must admit that those exciting days do not seem so very far away. Expand