HLA and insulin-dependent diabetes: an overview.

  title={HLA and insulin-dependent diabetes: an overview.},
  author={Arne Svejgaard and L P Ryder},
  journal={Genetic epidemiology},
  volume={6 1},
The present knowledge of the HLA system and its biological function is summarized as a basis for the subsequent discussion of the associations between this system and insulin-dependent diabetes (IDDM) and some mechanisms that may explain them. Although the serologically detectable DR determinants are still the most handy markers, there is now increasing evidence from studies of restriction enzyme fragment length polymorphism (RFLP) in IDDM that DQ determinants may play a primary role in causing… CONTINUE READING
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