HLA and infectious diseases.

  title={HLA and infectious diseases.},
  author={Jenefer M Blackwell and Sarra Elisabeth Jamieson and David Burgner},
  journal={Clinical microbiology reviews},
  volume={22 2},
  pages={370-85, Table of Contents}
Following their discovery in the early 1970s, classical human leukocyte antigen (HLA) loci have been the prototypical candidates for genetic susceptibility to infectious disease. Indeed, the original hypothesis for the extreme variability observed at HLA loci (H-2 in mice) was the major selective pressure from infectious diseases. Now that both the human genome and the molecular basis of innate and acquired immunity are understood in greater detail, do the classical HLA loci still stand out as… CONTINUE READING
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