HLA and autoimmunity in scleroderma (systemic sclerosis).

@article{Arnett1995HLAAA,
  title={HLA and autoimmunity in scleroderma (systemic sclerosis).},
  author={F. C. Arnett},
  journal={International reviews of immunology},
  year={1995},
  volume={12 2-4},
  pages={
          107-28
        }
}
Scleroderma or systemic sclerosis (SSc) has been associated with certain class II antigens of the major histocompatibility complex (MHC), including HLA-DR1, DR2, DR3, DR5, and DR52. In general, these earlier HLA correlations were weak and varied considerably among reporting centers and different ethnic populations. More recently, a variety of disease-specific autoantibodies have been discovered including anti-centromere, antitopoisomerase I, and a variety of anti-nucleolar antibodies. These… CONTINUE READING

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