HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection

@article{Khakoo2004HLAAN,
  title={HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection},
  author={Salim I. Khakoo and Chloe L. Thio and Maureen P. Martin and Collin R. Brooks and Xiaojiang Gao and Jacquie Astemborski and Jie Cheng and James J. Goedert and David Vlahov and Margaret W. Hilgartner and Steven T Cox and Ann-Margaret Little and Graeme J Alexander and Matthew E. Cramp and Stephen J. O’Brien and William M. Rosenberg and David L. Thomas and Mary N. Carrington},
  journal={Science},
  year={2004},
  volume={305},
  pages={872 - 874}
}
Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection. This effect was observed in Caucasians and African Americans with expected low… 
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The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.
Influence of inhibitory killer immunoglobulin-like receptors and their HLA-C ligands on resolving hepatitis C virus infection.
TLDR
This workshop component addressed the influence of KIR genotypes and their HLA ligands on resolving HCV infection and the implications of the results of the study of Lopez-Vazquez et al. on KIR and HCV disease progression.
Natural Killer Cell Function and Dysfunction in Hepatitis C Virus Infection
TLDR
Direct in vivo and in vitro evidence of compromised NK function in chronic HCV infection in conjunction with significant epidemiological associations between the outcome ofHCV infection and certain combinations of NK cell regulatory receptor and class I human histocompatibility linked antigen (HLA) genotypes indicate that NK cells are important in the immune response against HCV infections.
Are KIR-HLA Polymorphisms Relevant for the Outcome of Chronic Infected Hepatitis C Virus Patients?
TLDR
Improving understanding of NK cells could help to gain further insight into the virus-host interaction and the mechanisms of viral persistence, and there is a great potential for the use of KIR genes as a prognostic tool for the development of complications such as liver cirrhosis and HCC.
Decreased interferon‐γ production by NK cells from KIR haplotype B carriers in hepatitis C virus infection
  • D. Mele, A. Pasi, S. Varchetta
  • Biology, Medicine
    Liver international : official journal of the International Association for the Study of the Liver
  • 2019
TLDR
This work analysed whether its expression may affect natural killer (NK) cell function in the presence or absence of its principal ligand HLA‐Bw4 in KIR haplotype A and B carriers, which are characterized by a different representation of activating and inhibitory KIRs.
Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture.
TLDR
It is found that the KIR3DS1 ligand HLA-F is up-regulated on HCV-infected cells, and that interactions between KIR2DS1 and HLAF contribute to NK cell-mediated control of HCV.
KIR2DL2 Enhances Protective and Detrimental HLA Class I-Mediated Immunity in Chronic Viral Infection
TLDR
It is concluded that inhibitory KIRs, in synergy with T cells, are a major determinant of the outcome of persistent viral infection.
Epitope and the Killer Cell Immunoglobulin-Like Receptor 3 DS 1 Gene against the Development of Hepatocellular Carcinoma in Patients with Hepatitis C Virus Infection
TLDR
It was found that the human leukocyte antigen–Bw4I80 epitope and the KIR3DS1 gene were more frequent in HCV carriers than in patients with hepatocellular carcinoma.
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TLDR
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