HLA and HIV: modeling adaptation to moving targets

Abstract

Analysis of complex traits is a central challenge in medical genetics. Unearthing the genes and alleles contributing to susceptibility to disease, to drug toxicity, or efficacy demands the ability to separate true from false signals indicating associations. This is not trivial and demands imaginative alternatives to classical statistics to quantify small… (More)
DOI: 10.1038/sj.tpj.6500200

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