HLA allotype expressivity in transplantation.

  title={HLA allotype expressivity in transplantation.},
  author={Marcelo A. Fernandez-Vina},
  volume={124 26},
In this issue of Blood , Petersdorf et al observe more adverse outcomes in hematopoietic stem cell transplantation with unrelated donors when the patient's mismatched HLA-C allele has a high level of expression.[1][1] The authors imputed the expression levels of each HLA-C allele present in each of 
2 Citations
Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR
The National Marrow Donor Program and the Center for International Blood and Marrow Transplant Research, jointly with the NMDP Histocompatibility Advisory Group, provide evidence-based guidelines for optimal selection of unrelated donors and cord blood units.
Relevance of Polymorphic KIR and HLA Class I Genes in NK-Cell-Based Immunotherapies for Adult Leukemic Patients
A review of the polymorphic KIR and HLA class I genes that modulate the NK cell repertoire and how these markers can improve the outcomes of patients with acute leukemia and the emerging NK-cell-based immunotherapies for leukemic patients in addition to HSCT.


Identification of a permissible HLA mismatch in hematopoietic stem cell transplantation.
Hematopoietic stem cell transplantation with unrelated donors showed no association between the HLA-C allele mismatches (CAMMs) and adverse outcomes; antigen mismatches at this and mismatches other HLA loci are deleterious.
HLA-C expression levels define permissible mismatches in hematopoietic cell transplantation.
HLA-C expression levels provide new information on mismatches that should be avoided and extend understanding of HLA- C-mediated immune responses in human disease.
Multiple mismatches at the low expression HLA loci DP, DQ, and DRB3/4/5 associate with adverse outcomes in hematopoietic stem cell transplantation.
Prospective evaluation of matching for HLA-DRB3/4/5, -DQ, and -DP loci is warranted to reduce posttransplant risks in donor-recipient pairs matched for 7/8 HEL.
High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism.
Evidence is provided to elucidate the mechanism of aGVHD on the basis of HLA molecule and the identification of high-risk mismatch, that is, nonpermissive mismatch, would be beneficial for the selection of a suitable donor.
Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome.
It is concluded that matching for HLA-C should be incorporated into algorithms for unrelated donor selection, and when clinical circumstances allow, high-resolution class I typing may help optimize donor selection and improve outcome.
T-cell allorecognition: a case of mistaken identity or déjà vu?
Recent advances in the field are reviewed, showing that alloreactivity may sometimes result from cross-reactivity without molecular mimicry and at other times may result directly from TCR interactions with allogeneic pMHC surfaces that mimic the cognate ligand.
Influence of HLA-C Expression Level on HIV Control
It is demonstrated that increasing surface expression of HLA-C is associated with reduced viral load and reduced rate of progression to low CD4+ T cell counts in African and European Americans.
An intronic mutation responsible for a low level of expression of an HLA-A*24 allele.
Three members of a family in whom an HLA-A24 allele identified at the molecular level was typed as A "blank" by lymphocytotoxicity are described, whose serologically blank antigen was nevertheless faintly detectable by isoelectric focusing (IEF) and FACS analyses.
The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens
Most of the polymorphic amino acids of the class I histocompatibility antigen, HLA-A2, are clustered on top of the molecule in a large groove identified as the recognition site for processed foreign
High-throughput, high-fidelity HLA genotyping with deep sequencing
Overall, this technology has the capacity to deliver low-cost, high-throughput, and accurate HLA typing by multiplexing thousands of samples in a single sequencing run, which will enable comprehensive disease-association studies with large cohorts.