HLA alleles, IFN-gamma responses to HPV-11 E6, and disease severity in patients with recurrent respiratory papillomatosis.

@article{Bonagura2004HLAAI,
  title={HLA alleles, IFN-gamma responses to HPV-11 E6, and disease severity in patients with recurrent respiratory papillomatosis.},
  author={Vincent R Bonagura and Andrea Vambutas and James A Devoti and David W. Rosenthal and Bettie M. Steinberg and Allan L. Abramson and Mark J. Shikowitz and David Gjertson and Elaine F Reed},
  journal={Human immunology},
  year={2004},
  volume={65 8},
  pages={
          773-82
        }
}
Recurrent respiratory papillomatosis (RRP) remains an immunologic enigma. Human papillomavirus (HPV) types 6 and 11 are the predominant HPV viruses that cause papilloma development. However, it is unclear why only a very small fraction of HPV-exposed individuals develop RRP. We performed high-resolution HLA class I and II genotyping on 70 randomly selected patients (56 Caucasians and 14 African-Americans) with RRP. We report, for the first time, an increased frequency of HLA-DRB1*0102 in… CONTINUE READING
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